Pair Name | Tiliroside, Anti-MUC1 antibody | |||
Partner Name | Tiliroside | |||
Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
Gene Regulation | Down-regulation | Expression | NFKB1 | hsa4790 |
In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
Result | The combined action of anti-MUC1 and tiliroside was more effective in comparison with monotherapy in the case of C1GalT1, ST3GalT1, FUT4, Gal-3, NF-κB, Akt mRNAs, and Tn antigen, as well as sialyl T antigen expression. The results of our study indicate that applied combined therapy may be a promising anti-gastric cancer strategy. |
Pair Name | Rosmarinic acid, Anti-MUC1 antibody | |||
Partner Name | Rosmarinic acid | |||
Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
Down-regulation | Expression | BCL-xL | hsa598 | |
Up-regulation | Expression | CASP3 | hsa836 | |
Up-regulation | Expression | CASP9 | hsa842 | |
Down-regulation | Expression | LGALS3 | hsa3958 | |
Up-regulation | Expression | MUC1 | hsa4582 | |
Up-regulation | Expression | TP53 | hsa7157 | |
In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
Result | Results of the study indicate that combined action of anti-MUC1 and RA is more effective than monotherapy in relation to examined cancer related factors. Such treatment can be considered as new, promising strategy in gastric cancer therapy. |
No. | Title | Href |
---|---|---|
1 | Tiliroside Combined with Anti-MUC1 Monoclonal Antibody as Promising Anti-Cancer Strategy in AGS Cancer Cells. Int J Mol Sci. 2023 Aug 22;24(17):13036. doi: 10.3390/ijms241713036. | Click |
2 | Anti-cancer effect of combined action of anti-MUC1 and rosmarinic acid in AGS gastric cancer cells. Eur J Pharmacol. 2021 Jul 5;902:174119. doi: 10.1016/j.ejphar.2021.174119. | Click |