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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name Anti-MUC1 antibody
Drug Type Not Available
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 999
Pair Name Tiliroside, Anti-MUC1 antibody
Partner Name Tiliroside
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Gene Regulation Down-regulation Expression NFKB1 hsa4790
In Vitro Model AGS Gastric adenocarcinoma Homo sapiens (Human) CVCL_0139
Result The combined action of anti-MUC1 and tiliroside was more effective in comparison with monotherapy in the case of C1GalT1, ST3GalT1, FUT4, Gal-3, NF-κB, Akt mRNAs, and Tn antigen, as well as sialyl T antigen expression. The results of our study indicate that applied combined therapy may be a promising anti-gastric cancer strategy.
Combination Pair ID: 320
Pair Name Rosmarinic acid, Anti-MUC1 antibody
Partner Name Rosmarinic acid
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BCL-xL hsa598
Up-regulation Expression CASP3 hsa836
Up-regulation Expression CASP9 hsa842
Down-regulation Expression LGALS3 hsa3958
Up-regulation Expression MUC1 hsa4582
Up-regulation Expression TP53 hsa7157
In Vitro Model AGS Gastric adenocarcinoma Homo sapiens (Human) CVCL_0139
Result Results of the study indicate that combined action of anti-MUC1 and RA is more effective than monotherapy in relation to examined cancer related factors. Such treatment can be considered as new, promising strategy in gastric cancer therapy.
03. Reference
No. Title Href
1 Tiliroside Combined with Anti-MUC1 Monoclonal Antibody as Promising Anti-Cancer Strategy in AGS Cancer Cells. Int J Mol Sci. 2023 Aug 22;24(17):13036. doi: 10.3390/ijms241713036. Click
2 Anti-cancer effect of combined action of anti-MUC1 and rosmarinic acid in AGS gastric cancer cells. Eur J Pharmacol. 2021 Jul 5;902:174119. doi: 10.1016/j.ejphar.2021.174119. Click
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